11-beta-Hydroxysteroid Dehydrogenase Type 2

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

Also Known As:

11 beta-Hydroxysteroid Dehydrogenase Type 2; 11 beta-HSD2; 11beta-HSD2; 11beta-HSD2 Reductase; 11beta-Hydroxysteroid Dehydrogenase Type 2; 11 beta Hydroxysteroid Dehydrogenase Type 2; 11beta Hydroxysteroid Dehydrogenase Type 2

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Hydroxysteroid Dehydrogenases: 313
        11-beta-Hydroxysteroid Dehydrogenases: 265
        11-beta-Hydroxysteroid Dehydrogenase Type 2: 193
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        11-beta-Hydroxysteroid Dehydrogenases: 265
        11-beta-Hydroxysteroid Dehydrogenase Type 2: 193

Zigmunt Krozowski Selected Research

Zigmunt Krozowski Research Topics

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